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What is tramadol?buy Tramadol 10mg without prescription
Tramadol is an opioid agonist that can be used to treat moderate to moderately severe chronic pain in adults.buy Tramadol 100mg without prescription

Tramadol extended-release is used in adults who need around-the-clock pain treatment for a long period of time.
Brands of tramadol include ConZip, Qdolo, Ultram, and Ultram ER. Generic tramadol is available.

Tramadol was first approved by the FDA on March 3, 1995. It was originally classified as a non-controlled substance, but in 2014 it was reclassified to Schedule IV of the Controlled Substances Act with restrictions on its prescribing.

Is Tramadol an Opioid?
Tramadol is an opioid pain medication that also has non-opioid effects. It differs from other opioids in that it is a prodrug and must be metabolized in the body before it becomes active. Tramadol itself has very little activity at the mu-opioid receptor (MOR), but its M1 metabolite (O-desmethyl-tramadol) has an affinity only 10 times lower than that of morphine. Binding to the mu-opioid receptor triggers intracellular events that reduce the transmission of pain signals, which blunts the emotional response to pain and provides pain relief.

How Do Genetics Affect Tramadol?
The opioid effects of tramadol are heavily influenced by a person’s genetics, specifically their ability to metabolize tramadol via a liver enzyme system called cytochrome P450 2D6. 20% of African Americans, 10% of Caucasians, and 2% of Asians have genetic polymorphisms that reduce the activity of this enzyme, which reduces the amount of tramadol metabolized. People who are poor metabolizers of CYP 2D6 may find tramadol ineffective.